Immunoglobulin G-degrading enzyme of Streptococcus pyogenes (IdeS) is an enzyme that particularly cleaves immunoglobulin G (IgG). Our strategy takes advantage of the capacity of IdeS to especially as well as effectively suspend human IgG antibodies, to stop as well as treat clients that have established pathogenic IgG. IdeS-mediated IgG degradation is a new restorative principle for treatment of IgG-driven human conditions.
IdeS has been pre-clinically examined relating to efficiency and safety and security. The restorative impact of IdeS has been studied in various disease models; e.g. collagen antibody induced arthritis (CAIA), idiopathic thrombocytopenic purpura (ITP) and also Goodpasture’s condition (GENERAL PRACTITIONER). IdeS was found to effectively neutralize IgG in all 3 models. Experiments on lotion collected from extremely sensitized kidney patients plainly showed that IdeS rapidly decreased the level of anti-HLA antibodies which IdeS could turn a positive cross-match right into an adverse.
This was a strong support for us to even more examine IdeS for desensitization of clients before transplant.
Our initial professional studies are focused on desensitization of HLA-immunized individuals prior to kidney transplantation and also treatment of antibody mediated graft rejection. Past transplantation, we have actually identified healing options for IdeS treatment within the locations of neurology, nephrology and hematology.