Hansa Medical acquires rights to cancer immunotherapy using antibody-modulating enzymes

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Hansa Medical AB (publ) today revealed the acquisition of UK based Immago Biosystems Ltd, a College of Oxford-spinout concentrated on the improvement of antibody based cancer cells therapies making use of antibody-modulating enzymes.

The founders of Immago Biosystems, Dr Chris Scanlan and also Dr Max Crispin at the Glycoprotein Rehabs Research Laboratory, at the College of Oxford, have uncovered that IgG-antibody regulating enzymes can enhance the efficiency of antibody based cancer cells therapies.

Along with their associate, Dr Kavitha Baruah, they created Immago Biosystems Ltd to help bring these concepts to the center. Immago Biosystems has actually applied for license defense for this principle, as well as the study outcomes have ultimately been released in the Journal of Molecular Biology, 2012 Jun 29; 420( 1-2):1 -7.

Hansa Medical has just recently confirmed the study searchings for by integrating its lead candidate IdeS with accepted anti-cancer antibodies in preclinical cancer cells models, as well as has requested additional patent security in this field.

” By integrating IdeS with a restorative antibody, the artificial insemination and also in vivo efficacy of the antibody is dramatically boosted with conserved uniqueness. Possibly, this suggests that presently available antibody based cancer therapies could be made much more reliable”, commented Dr Christian Kjellman, Senior Vice Head Of State, R&D at Hansa Medical Abdominal Muscle.

” Our verification of the study searchings for by Immago has urged us to further take a look at the potential of IdeS as well as EndoS within cancer cells immunotherapy. Although the findings are to be regarded as early preclinical research study findings, our company believe that this principle can hold significant capacity for IdeS and EndoS along with the emphasis of our existing clinical program in transplant as well as autoimmunity,” claimed Göran Arvidson, CEO of Hansa Medical AB.

The global market for monoclonal antibodies (mAbs) for cancer cells is estimated at $23 billion, and also is expected to expand to $33 billion by 2017, according to Cancer Monoclonal Antibodies Market Projection to 2017 (August 13, 2013).

The amount of the procurement was not revealed. The purchase will not have a significant effect on the Hansa Medical result for 2016.

The information in this news release is revealed according to the EU Market Misuse Guideline. The information was launched for public disclosure through the agency of the get in touch with person stated below on July 19, 2016 at 13.00 CET.

Regarding the antibody enhancement modern technology by Immago Biosystems
Several antibody based cancer treatments depend on activation of the immune system through so called Antibody Dependent Cell mediated Cytotoxicity (ADCC). These antibodies bind to antigens on cancer cells and when affixed, the antibody brings in immune cells via the Fc-gamma receptors externally of cytotoxic immune cells, which after that destroy the cancer cells. At physiological problems, most of Fc-gamma receptors are bound to normally occurring antibodies from the plasma, so activation of immune cells by a restorative antibody is dependent upon the variation of unimportant plasma antibodies before binding. Pretreatment with IdeS or EndoS before treatment with an antibody based cancer cells therapy, displaces the unnecessary antibodies, leaving room for the restorative antibodies to bind to Fc-gamma receptors on the surface of immune cells. This causes cytotoxic immune cells with a considerably higher lots of healing antibodies guided in the direction of cancer cells. For more details, please see www.hansamedical.com/antibodyenhancement

Concerning Immago Biosystems Ltd

Immago Biosystems Ltd was founded in 2013 from study emerging in the Oxford Glycobiology Institute within the Division of Biochemistry at the College of Oxford. Dr Chris Scanlan and also Dr Max Crispin designed ‘receptor redoubling’ which aims to enhances immune-mediated killing of cancer cells by modulating the endogenous antibody arsenal with enzymes such as IdeS and also EndoS. Together with their colleague, Dr Kavitha Baruah, they created Immago Biosystems Ltd to aid bring these concepts to the facility.

Concerning Dr Chris Scanlan

Dr Chris Scanlan was a team leader in the Oxford Glycobiology Institute at the College of Oxford, as well as held lectureships at Corpus Christi College and Oriel College, Oxford. Dr Scanlan died from cancer in 2013, aged simply 35. Dr Scanlan made influential contributions to immunology as well as the international initiative to create an HIV injection, with among his crucial papers bring in over 650 citations. His later work concentrated on biotherapeutics against cancer. It was this job, with Dr Max Crispin, that resulted in the beginning of Immago Biosytems.

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